{{Rsnum
|rsid=11761231
|Chromosome=7
|position=131685280
|Orientation=plus
|GMAF=0.4334
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 37.2 | 44.2 | 18.6
| HCB | 6.6 | 40.9 | 52.6
| JPT | 8.8 | 46.9 | 44.2
| YRI | 67.3 | 30.6 | 2.0
| ASW | 50.9 | 42.1 | 7.0
| CHB | 6.6 | 40.9 | 52.6
| CHD | 8.3 | 28.7 | 63.0
| GIH | 30.7 | 42.6 | 26.7
| LWK | 60.0 | 35.5 | 4.5
| MEX | 31.0 | 41.4 | 27.6
| MKK | 55.8 | 41.0 | 3.2
| TSI | 45.1 | 41.2 | 13.7
| HapMapRevision=28
}}[[rs11761231]] has been reported in a large study to be associated with [[rheumatoid arthritis]], particularly in females.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.44 (CI 1.19-1.75), and for homozygotes, 1.64 (CI 1.35-1.99). {{PMID|17554300|OA=1
}}

{{PMID|19116934|OA=1
}} The association between [[rs11761231]] and rheumatoid arthritis did not reproduce in a North American population, emphasizing "the need to carefully account for population structure to avoid false-positive disease associations".

{{GWAS Summary
|SNP=rs11761231
|PubMedID=17554300
|Condition=Rheumatoid arthritis
|Gene=Intergenic
|Risk Allele=C
|pValue=4.00E-007
|OR=1.32
|OA=1
}}

{{PharmGKB
|RSID=rs11761231
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,860 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs11761231-C). This variant is associated with rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356639
}}

{{PMID|18224312|OA=1
}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

{{PMID|18794857|OA=1
}} Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

{{PMID|19445664|OA=1
}} Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.

{{PMID|20017963|OA=1
}} Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11761231
|overall_frequency_n=87
|overall_frequency_d=128
|overall_frequency=0.679688
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}