{{Rsnum
|rsid=118192161
|Chromosome=19
|Orientation=plus
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=RYR1
|position=38444211
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=118192161
|variant=0004
}}{{ClinVar
|rsid=118192161
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=38934851
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38934851C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=180901.0004
|CLNSIG=255
|CLNCUI=C0024591; C0751951
|CLNDBN=Malignant hyperthermia; Central core disease; Malignant melanoma
|Disease=Malignant hyperthermia; Central core disease; Malignant melanoma
|CLNACC=RCV000013833.2; RCV000013834.24; RCV000063528.2
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:Orphanet:SNOMED_CT; MedGen:SNOMED_CT
|CLNDSDBID=NBK1146:C0024591:145600:423; NBK1290:NBK1391:C0751951:117000:597:598:43152001; C0025202:2092003
}}

[[rs118192161]], aka p.Arg163Cys or p.R163C, is a SNP in the [[RYR1]] gene leading to increased susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID|8220423}} Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia.

{{PMID|21499247|OA=1
}} Exome sequencing identifies GRIN2A as frequently mutated in melanoma.

{{PMID|8592342|OA=1
}} Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia.