{{Rsnum
|rsid=118192162
|Chromosome=19
|Orientation=plus
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene=RYR1
|position=38455359
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=118192162
|variant=0031
}}{{ClinVar
|rsid=118192162
|Reversed=0
|FwdREF=A
|FwdALT=C,G
|REF=A
|ALT=C,G
|RSPOS=38945999
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38945999A>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=180901.0031
|CLNSIG=255
|CLNCUI=C0024591; C0751951,.
|CLNDBN=Malignant hyperthermia; Central core disease
|Disease=Malignant hyperthermia; Central core disease
|CLNACC=RCV000013865.1; RCV000013866.16
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:Orphanet:SNOMED_CT
|CLNDSDBID=NBK1146:C0024591:145600:423; NBK1290:NBK1391:C0751951:117000:597:598:43152001
}}

[[rs118192162]], aka p.Tyr522Ser or p.Y522S, is a SNP in the [[RYR1]] gene leading to increased susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID Auto
|PMID=7829078
|Title=Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores.
}}

{{PMID Auto
|PMID=19020143
|Title=A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser.
}}