{{Rsnum
|rsid=118192175
|Chromosome=19
|Orientation=plus
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=RYR1
|position=38494564
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=118192175
|variant=0010
}}{{ClinVar
|rsid=118192175
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=38985204
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38985204C>T
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1391; 180901.0010
|CLNSIG=255
|CLNCUI=C0024591
|CLNDBN=Malignant hyperthermia; Central core disease
|Disease=Malignant hyperthermia; Central core disease
|CLNACC=RCV000013840.1; RCV000056223.1
|Tags=PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:Orphanet:SNOMED_CT
|CLNDSDBID=NBK1146:C0024591:145600:423; NBK1290:NBK1391:C0751951:117000:597:598:43152001
}}

[[rs118192175]], aka p.Arg2163Cys or p.R2163C, is a SNP in the [[RYR1]] gene leading to increased susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID Auto
|PMID=9497245
|Title=Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation.
|OA=1
}}

{{PMID Auto
|PMID=12124989
|Title=RYR1 mutations causing central core disease are associated with more severe malignant hyperthermia in vitro contracture test phenotypes.
}}