{{Rsnum
|rsid=118192176
|Chromosome=19
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=RYR1
|position=38494579
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=118192176
|variant=0013
}}{{ClinVar
|rsid=118192176
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=38985219
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38985219G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=180901.0013
|CLNSIG=255
|CLNCUI=C0024591
|CLNDBN=Malignant hyperthermia
|Disease=Malignant hyperthermia
|CLNACC=RCV000013845.1
|Tags=PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1146:C0024591:145600:423
}}

[[rs118192176]], aka p.Val2168Met or p.V2168M, is a SNP in the [[RYR1]] gene leading to increased susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID Auto
|PMID=9497245
|Title=Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation.
|OA=1
}}

{{PMID Auto
|PMID=12059893
|Title=Mutation screening in the ryanodine receptor 1 gene (RYR1) in patients susceptible to malignant hyperthermia who show definite IVCT results: identification of three novel mutations.
}}

{{PMID Auto
|PMID=12434264
|Title=[Current aspects of the diagnosis of malignant hyperthermia].
}}

{{PMID Auto
|PMID=16917943
|Title=Mutations in RYR1 in malignant hyperthermia and central core disease.
}}

{{PMID Auto
|PMID=17710899
|Title=Molecular genetic detection of susceptibility to malignant hyperthermia in Belgian families.
}}