{{Rsnum
|rsid=11833579
|Gene=NINJ2
|Chromosome=12
|position=666033
|Orientation=plus
|GMAF=0.281
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 34.8 | 58.9
| HCB | 12.7 | 41.8 | 45.5
| JPT | 12.6 | 56.8 | 30.6
| YRI | 5.4 | 34.0 | 60.5
| ASW | 3.5 | 28.1 | 68.4
| CHB | 12.7 | 41.8 | 45.5
| CHD | 9.3 | 53.3 | 37.4
| GIH | 11.1 | 44.4 | 44.4
| LWK | 3.8 | 27.4 | 68.9
| MEX | 21.4 | 44.6 | 33.9
| MKK | 3.9 | 27.3 | 68.8
| TSI | 9.8 | 39.2 | 51.0
| HapMapRevision=28
}}[[rs11833579]] is one of 2 SNPs found near the [[NINJ2]] gene on chromosome 12 associated with increased risk for both total stroke and ischemic [[stroke]], based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is [[rs12425791]].

Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP.
{{doi|10.1056/NEJMoa0900094}}

Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either [[rs12425791]] or [[rs11833579]] and ischemic (or incident) stroke.[http://content.nejm.org/cgi/content/short/362/16/1547]

{{omim
|id=601367
|rsnum=11833579
}}

{{PMID Auto
|PMID=21722921
|Title=NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
}}

{{PMID Auto
|PMID=21832970
|Title=Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
}}

{{PMID Auto
|PMID=22011019
|Title=Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
}}

{{PMID Auto
|PMID=22212150
|Title=Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
|OA=1
}}

{{PMID Auto
|PMID=22429733
|Title=NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
|OA=1
}}

{{PMID Auto
|PMID=19369658
|Title=Genomewide association studies of stroke.
|OA=1
}}

{{PMID Auto
|PMID=20448654
|Title=Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
}}

{{PMID Auto
|PMID=20957003
|Title=[Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district].
}}

{{PMID Auto
|PMID=21376321
|Title=No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
}}

{{PMID Auto
|PMID=22297388
|Title=Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
}}

{{PMID Auto
|PMID=23270316
|Title=Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis
}}

{{PMID Auto
|PMID=22938733
|Title=Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population
}}

{{PMID Auto
|PMID=22795341
|Title=The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.
}}

{{PMID Auto
|PMID=25096477
|Title=Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis
}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}