{{Rsnum
|rsid=11868035
|Gene=SREBF1
|Chromosome=17
|position=17811787
|Orientation=plus
|GMAF=0.4692
|Gene_s=RAI1,SREBF1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 40.2 | 51.8
| HCB | 69.3 | 27.0 | 3.6
| JPT | 66.4 | 28.3 | 5.3
| YRI | 2.7 | 39.5 | 57.8
| ASW | 3.5 | 45.6 | 50.9
| CHB | 69.3 | 27.0 | 3.6
| CHD | 76.6 | 21.5 | 1.9
| GIH | 50.5 | 42.6 | 6.9
| LWK | 8.2 | 30.9 | 60.9
| MEX | 17.2 | 53.4 | 29.3
| MKK | 12.9 | 38.1 | 49.0
| TSI | 11.9 | 55.4 | 32.7
| HapMapRevision=28
}}
[[rs11868035]] is one of several SNPs associated with the [[SREBF1]] gene that show a modest association with [[type-2 diabetes]]. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, [[rs11868035]](A), in the orientation as in dbSNP. {{PMID|18192539}}

{{PMID|18692268}} [[type-2 diabetes]] [[rs2297508]](C) and [[rs11868035]](C)

This SNP [[rs11868035]] and [[rs1057217]] are associated with increased risk of [[schizophrenia]] in German and Scandinavian samples. {{PMID|18936756}}

This SNP and [[rs6812193]] are reported to affect risk of [[Parkinson's disease]]. {{PMID|21738487|OA=1
}} [http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002141 plos]  

{{ neighbor
| rsid = 2297508
| distance = 216
}}

{{PharmGKB
|RSID=rs11868035
|Name_s=
|Gene_s=RAI1, SREBF1
|Feature=
|Evidence=PubMed ID:18936756
|Annotation=This SNP in the SREBF1 gene was strongly associated with schizophrenia in German, Danish and Norwegian samples.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162355925
}}

{{PMID Auto
|PMID=22531747
|Title=Association study between two novel single nucleotide polymorphisms and sporadic Parkinson's disease in Chinese Han population
}}

{{PMID Auto
|PMID=22678801
|Title=[Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]
}}

{{PMID|17019602|OA=1
}} Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11868035
|overall_frequency_n=51
|overall_frequency_d=126
|overall_frequency=0.404762
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24152445
|Title=Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}