{{Rsnum
|rsid=11898505
|Gene=SPTBN1
|Chromosome=2
|position=54457420
|Orientation=plus
|GMAF=0.1988
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SPTBN1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.9 | 47.8 | 36.3
| HCB | 1.5 | 16.8 | 81.8
| JPT | 1.8 | 33.6 | 64.6
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 14.0 | 86.0
| CHB | 1.5 | 16.8 | 81.8
| CHD | 1.8 | 23.9 | 74.3
| GIH | 2.0 | 30.7 | 67.3
| LWK | 0.0 | 1.9 | 98.1
| MEX | 6.9 | 31.0 | 62.1
| MKK | 0.0 | 5.8 | 94.2
| TSI | 6.9 | 48.5 | 44.6
| HapMapRevision=28
}}rs11898505 increases susceptibility to Osteoporotic fractures for carriers of the G allele {{PMID|18445777}}

{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (spine)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=G
|Pval=0.000004
|OR=0.07
|ORtxt=[0.04-0.10] SD decrease
}}

{{PMID Auto GWAS
|PMID=19801982
|Trait=Bone mineral density (spine)
|Title=Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
|RiskAllele=A
|Pval=2E-8
|OR=0.07
|ORtxt=[0.05-0.09] sd increase
|OA=1
}}

{{PharmGKB
|RSID=rs11898505
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 2p16.2; Reported Gene(s): SPTBN1; Risk Allele: rs11898505-G); (p-value= 0.000004).This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740139
}}

{{PMID Auto
|PMID=19629617
|Title=Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
|OA=1
}}

{{PMID Auto
|PMID=20554715
|Title=Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11898505
|overall_frequency_n=27
|overall_frequency_d=34
|overall_frequency=0.794118
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22798246
|Title=The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}