{{Rsnum
|rsid=11931074
|Chromosome=4
|position=89718364
|Orientation=plus
|GMAF=0.3545
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 84.8 | 14.3 | 0.9
| HCB | 24.8 | 51.8 | 23.4
| JPT | 17.7 | 46.9 | 35.4
| YRI | 13.6 | 38.8 | 47.6
| ASW | 19.3 | 49.1 | 31.6
| CHB | 24.8 | 51.8 | 23.4
| CHD | 17.4 | 54.1 | 28.4
| GIH | 53.0 | 44.0 | 3.0
| LWK | 12.8 | 47.7 | 39.4
| MEX | 43.1 | 44.8 | 12.1
| MKK | 13.5 | 50.6 | 35.9
| TSI | 85.3 | 12.7 | 2.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19915576
|Trait=Parkinson's disease
|Title=Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
|RiskAllele=G
|Pval=7E-17
|OR=1.37
|ORtxt=[1.27-1.48]
}}

{{omim
|id=146500
|rsnum=11931074
}}

{{PMID Auto
|PMID=21853288
|Title=Variant in the 3' region of SNCA associated with Parkinson's disease and serum ?-synuclein levels.
}}

{{PMID Auto
|PMID=19063963
|Title=Genetic susceptibility in Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=19771175
|Title=Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.
|OA=1
}}

{{PMID Auto
|PMID=19915575
|Title=Genome-wide association study reveals genetic risk underlying Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=20070850
|Title=Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
|OA=1
}}

{{PMID Auto
|PMID=20413655
|Title=Genetics of neurodegenerative diseases: insights from high-throughput resequencing.
|OA=1
}}

{{PMID Auto
|PMID=21391235
|Title=Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11931074
|overall_frequency_n=48
|overall_frequency_d=128
|overall_frequency=0.375
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23182315
|Title=Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort
}}

{{PMID Auto
|PMID=23820587
|Title=Alzheimer's disease and Parkinson's disease genome-wide association study top hits and risk of Parkinson's disease in Korean population
}}

{{PMID Auto
|PMID=23853107
|Title=Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China
}}

{{PMID Auto
|PMID=23962496
|Title=The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}