{{Rsnum
|rsid=12026
|Gene=PON2
|Chromosome=7
|position=95411704
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.2548
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PON2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 55.4 | 40.0 | 4.6
| HCB | 62.2 | 35.6 | 2.2
| JPT | 63.6 | 29.5 | 6.8
| YRI | 46.8 | 40.3 | 12.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 62.2 | 35.6 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|9329371}} reports that one or two copies of a common variation (glycine replacing alanine) present at amino acid 148 of the [[PON2]] protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).

{{ neighbor
| rsid = 17876142
| distance = 1
}}

{{omim
|id=602447
|rsnum=12026
|variant=0002
}}

{{ClinVar
|rsid=12026
|Reversed=1
|FwdREF=C
|FwdALT=G
|REF=G
|ALT=C
|RSPOS=95041016
|CHROM=7
|GMAF=0.255
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05037800000017051f110101
|GENEINFO=PON2:5445
|GENE_NAME=PON2
|GENE_ID=5445
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.95041016G>C
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7452; 0.2548
|CLNACC=RCV000007501.1
|CLNDBN=PARAOXONASE 2 POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=602447.0002
|COMMON=1
|Disease=PARAOXONASE 2 POLYMORPHISM
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=21223581
|Title=Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
|OA=1
}}

{{GET Evidence
|gene=PON2
|aa_change=Ala148Gly
|aa_change_short=A148G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12026
|overall_frequency_n=2645
|overall_frequency_d=10758
|overall_frequency=0.245864
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|nblosum100=1
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23327886
|Title=Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.
}}

{{PMID Auto
|PMID=24100645
|Title=Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}