{{Rsnum
|rsid=12044355
|Gene=DISC1
|Chromosome=1
|position=231708601
|Orientation=plus
|GMAF=0.3255
|Gene_s=DISC1,MAP1LC3C
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 39.3 | 45.5 | 15.2
| HCB | 35.0 | 47.4 | 17.5
| JPT | 31.9 | 53.1 | 15.0
| YRI | 83.7 | 16.3 | 0.0
| ASW | 56.1 | 35.1 | 8.8
| CHB | 35.0 | 47.4 | 17.5
| CHD | 35.8 | 46.8 | 17.4
| GIH | 62.4 | 31.7 | 5.9
| LWK | 82.7 | 15.5 | 1.8
| MEX | 39.7 | 51.7 | 8.6
| MKK | 73.1 | 25.0 | 1.9
| TSI | 45.1 | 43.1 | 11.8
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19118814
|Trait=Alzheimer's disease
|Title=Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
|RiskAllele=
|Pval=0.000009
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs12044355
|Name_s=
|Gene_s=DISC1
|Feature=
|Evidence=PubMed ID:19118814; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (Initial Sample Size: 492 cases, 496 controls; Replication Sample Size: 238 cases, 220 controls); (Region: 1q42.2; Reported Gene(s): DISC1; Risk Allele: rs12044355-?); (p-value= 0.000009).This variant is associated with Alzheimer's disease.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740090
}}

{{PharmGKB
|RSID=rs12044355
|Name_s=
|Gene_s=DISC1
|Feature=
|Evidence=PubMed ID:19118814
|Annotation=This variant is significantly associated with late-onset Alzheimer disease (LOAD) in a GWAS study with 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162363840
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12044355
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}