{{Rsnum
|rsid=12044852
|Gene=CD58
|Chromosome=1
|position=116545157
|Orientation=plus
|GMAF=0.2383
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=CD58
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 2.7 | 20.4 | 77.0
| HCB | 29.9 | 46.0 | 24.1
| JPT | 42.5 | 39.8 | 17.7
| YRI | 0.0 | 11.6 | 88.4
| ASW | 1.8 | 8.8 | 89.5
| CHB | 29.9 | 46.0 | 24.1
| CHD | 28.4 | 47.7 | 23.9
| GIH | 6.9 | 39.6 | 53.5
| LWK | 0.0 | 10.0 | 90.0
| MEX | 6.9 | 31.0 | 62.1
| MKK | 0.0 | 17.3 | 82.7
| TSI | 2.0 | 19.6 | 78.4
| HapMapRevision=28
}}
[[rs12044852]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.24 (CI 1.12-1.37). {{PMID|17660530}}

{{PMID Auto
|PMID=18650830
|Title=Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians
}}

{{PharmGKB
|RSID=rs12044852
|Name_s=
|Gene_s=CD58
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356164
}}

{{omim
|id=126200
|rsnum=12044852
}}

{{PMID Auto
|PMID=21362770
|Title=Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts
|OA=1
}}

{{PMID Auto
|PMID=19237575
|Title=The role of the CD58 locus in multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20007504
|Title=Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
|OA=1
}}

{{PMID Auto
|PMID=20368992
|Title=Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.
|OA=1
}}

{{PMID Auto
|PMID=22411505
|Title=Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12044852
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24655566
|Title=CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}