{{Rsnum
|rsid=1205
|Gene=CRP
|Chromosome=1
|position=159712443
|Orientation=plus
|GMAF=0.365
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CRP
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.4 | 45.1 | 11.5
| HCB | 18.2 | 49.6 | 32.1
| JPT | 10.6 | 38.9 | 50.4
| YRI | 73.5 | 26.5 | 0.0
| ASW | 56.1 | 35.1 | 8.8
| CHB | 18.2 | 49.6 | 32.1
| CHD | 23.9 | 49.5 | 26.6
| GIH | 40.6 | 43.6 | 15.8
| LWK | 68.2 | 29.1 | 2.7
| MEX | 37.9 | 50.0 | 12.1
| MKK | 69.2 | 26.9 | 3.8
| TSI | 54.9 | 32.4 | 12.7
| HapMapRevision=28
}}Although somewhat lacking in statistical power, several reports have linked [[rs1205]], a synonymous mutation known as CRP4 in the C-reactive protein [[CRP]] to the autoimmune disorder [[SLE]], systemic [[lupus]] erythematosus. The risk allele in dbSNP orientation is (T). [PMID 14645206, PMID 15897982]

{{PMID|19139754|OA=1
}} C-reactive protein (CRP) levels [[obesity]] rs1205(G) allele had significantly higher CRP levels than noncarriers in a dose-dependent manner suggesting a possible association with fat localization

[http://blog.23andme.com/2009/06/30/genetic-study-casts-doubt-on-inflammatory-marker-as-cause-of-heart-disease/ 23andMe blog] each rs1205(T) lowered CRP by 20% but no association with heart disease.

{{omim
|desc=C-REACTIVE PROTEIN, PENTRAXIN-RELATED; CRP
|id=123260
|quiet=1
|rsnum=1205
|variant=
}}

{{PMID Auto
|PMID=19040303
|Title=C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain
}}

{{PMID Auto
|PMID=19433520
|Title=Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study
|OA=1
}}

{{omim
|desc=STROKE, ISCHEMIC
|id=601367
|rsnum=1205
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
|id=152700
|rsnum=1205
}}
{{PMID Auto
|PMID=19101671
|Title=Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity
}}
{{PMID Auto
|PMID=19692124
|Title=Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration
}}

{{PMID Auto
|PMID=19821022
|Title=Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
}}
{{PMID Auto
|PMID=19965533
|Title=CRP polymorphisms and progression of chronic kidney disease in African Americans
|OA=1
}}
{{PMID Auto
|PMID=20538124
|Title=Genetic Polymorphisms and the Cardiovascular Risk of Non-Steroidal Anti-Inflammatory Drugs
}}
{{PMID Auto
|PMID=20552244
|Title=Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia
}}
{{PMID Auto
|PMID=20733302
|Title=Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke
}}
{{PMID Auto
|PMID=20333461
|Title=Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population
}}
{{PMID Auto
|PMID=20856253
|Title=Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan
}}
{{PMID Auto
|PMID=20949557
|Title=Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival
|OA=1
}}

{{PMID Auto
|PMID=21293934
|Title=Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer
}}

{{omim
|id=613145
|rsnum=1205
}}

{{PMID Auto
|PMID=21413847
|Title=Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey
}}

{{PMID Auto
|PMID=21080913
|Title=The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study
}}

{{PMID Auto
|PMID=21575917
|Title=C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants
}}

{{PMID Auto
|PMID=22004660
|Title=Genetic Variants, Immune Function, and Risk of Pre-Eclampsia among American Indians
|OA=1
}}

{{PMID|16519819|OA=1
}} Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

{{PMID|16723442|OA=1
}} A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

{{PMID|16733231}} Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.

{{PMID|16820586|OA=1
}} Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

{{PMID|16832152}} Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

{{PMID|17101857}} Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey.

{{PMID|17697822}} Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).

{{PMID|17888441|OA=1
}} Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

{{PMID|17900590}} C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

{{PMID|17903293|OA=1
}} Genome-wide association with select biomarker traits in the Framingham Heart Study.

{{PMID|17956875}} DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.

{{PMID|18000615}} Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.

{{PMID|18162041|OA=1
}} Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

{{PMID|18167554|OA=1
}} C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

{{PMID|18216863|OA=1
}} Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

{{PMID|18285551}} Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

{{PMID|18385179}} Systemic inflammation, genetic susceptibility and lung function.

{{PMID|18394581|OA=1
}} Bayesian meta-analysis of genetic association studies with different sets of markers.

{{PMID|18439548|OA=1
}} Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

{{PMID|18500540|OA=1
}} Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

{{PMID|18700811|OA=1
}} Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.

{{PMID|18704199|OA=1
}} Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

{{PMID|18714381|OA=1
}} Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.

{{PMID|18714384|OA=1
}} The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

{{PMID|18793001|OA=1
}} Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

{{PMID|19075099}} Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.

{{PMID|19076828|OA=1
}} Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

{{PMID|19095725|OA=1
}} Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

{{PMID|19262552}} C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

{{PMID|19267250|OA=1
}} C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

{{PMID|19272152|OA=1
}} IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

{{PMID|19410251}} Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

{{PMID|19426506|OA=1
}} C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

{{PMID|19436291|OA=1
}} C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

{{PMID|19567438|OA=1
}} Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

{{PMID|19796676|OA=1
}} Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.

{{PMID|19906786|OA=1
}} Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

{{PMID|19962488|OA=1
}} Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.

{{PMID|20078877|OA=1
}} Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.

{{PMID|20616999|OA=1
}} Usefulness of Mendelian randomization in observational epidemiology.

{{PMID|20974458}} Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring.

{{PMID|21034294}} C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

{{PMID|21094359}} Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

{{PMID|21296145|OA=1
}} Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms.

{{PMID|21325005|OA=1
}} Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

{{PMID|21647738|OA=1
}} Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

{{PMID|21790705}} The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.

{{PMID|21979869|OA=1
}} C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

{{PMID Auto
|PMID=23212764
|Title=Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C&gt;T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma
}}

{{PMID Auto
|PMID=23254959
|Title=Serum C-reactive protein and risk of lung cancer: a case-control study
}}

{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=23940726
|Title=Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population
|OA=1
}}

{{PMID Auto
|PMID=24574329
|Title=Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant
}}

{{PMID Auto
|PMID=24602049
|Title=Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves
}}

{{PMID Auto
|PMID=23397258
|Title=Association study of CRP gene in systemic sclerosis in European Caucasian population.
}}

{{PMID Auto
|PMID=24862635
|Title=Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)
}}

{{PMID Auto
|PMID=24894103
|Title=Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis
}}

{{PMID Auto
|PMID=25025473
|Title=Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk
}}

{{PMID Auto
|PMID=25020710
|Title=P324Circadian genes in the regulation of lipids in coronary artery disease
}}
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