{{Rsnum
|rsid=12075
|Gene=ACKR1
|Chromosome=1
|position=159205564
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.4619
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ACKR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 28.3 | 54.9 | 16.8
| HCB | 0.7 | 10.9 | 88.3
| JPT | 0.9 | 20.4 | 78.8
| YRI | 100.0 | 0.0 | 0.0
| ASW | 78.9 | 19.3 | 1.8
| CHB | 0.7 | 10.9 | 88.3
| CHD | 0.0 | 4.6 | 95.4
| GIH | 12.9 | 53.5 | 33.7
| LWK | 0.0 | 0.0 | 0.0
| MEX | 19.0 | 51.7 | 29.3
| MKK | 97.4 | 2.6 | 0.0
| TSI | 32.4 | 52.9 | 14.7
| HapMapRevision=28
}}

{{Venter SNP
|rsid=12075
|allele=A
|frequency=0.517
|uid=1103675237185
|type=homozygous_SNP
|hugo=IGSF4B
|ensembl gene=ENSG00000162706
|ensembl transcript=ENST00000359381
|sift=TOLERATED
|disease=Individuals that do not produce the Duffy antigen (FY(A- B-)) are more resistant to vivax malaria. This allele is found predominantly in population of african origin.
}}

{{ neighbor
| rsid = 2814778
| distance = 671
}}
{{ neighbor
| rsid = 13962
| distance = 173
}}

{{PMID Auto
|PMID=20040767
|Title=Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators
|OA=1
}}

{{omim
|id=110700
|rsnum=12075
|variant=0001
}}

{{PMID Auto GWAS
|PMID=22037903
|Trait=None
|Title=Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
|RiskAllele=
|Pval=5E-24
|OR=1.2700
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=22291609
|Trait=None
|Title=A genome-wide association scan on the levels of markers of inflammation in sardinians reveals associations that underpin its complex regulation.
|RiskAllele=A
|Pval=4E-51
|OR=None
|ORtxt=None
|OA=1
}}

{{ClinVar
|rsid=12075
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=159205564
|CHROM=1
|GMAF=0.4615
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x050168000a0515051f130101
|GENEINFO=ACKR1:2532
|GENE_NAME=ACKR1
|GENE_ID=2532
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.159205564G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;NSM;REF;ASP;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.4619; 0.5381
|CLNACC=RCV000000005.1
|CLNDBN=DUFFY BLOOD GROUP SYSTEM, FYA/FYB POLYMORPHISM
|CLNSRC=ClinVar; OMIM Allelic Variant; dbRBC - Blood Group Antigen Gene Mutation Database
|CLNSRCID=NM_002036.3:c.125G>A; 613665.0001; 252
|COMMON=1
|Disease=DUFFY BLOOD GROUP SYSTEM
}}

{{PMID Auto
|PMID=16254603
|Title=Perspectives on human genetic variation from the HapMap Project.
|OA=1
}}

{{PMID Auto
|PMID=16255080
|Title=A haplotype map of the human genome.
|OA=1
}}

{{PMID Auto
|PMID=19737746
|Title=Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
|OA=1
}}

{{PMID Auto
|PMID=21156192
|Title=A Duffy antigen receptor for chemokines (DARC) polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis C infection.
}}

{{PMID Auto
|PMID=21257350
|Title=DNA-based methods in the immunohematology reference laboratory.
|OA=1
}}

{{PMID Auto
|PMID=23017229
|Title=Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children
|OA=1
}}

{{GET Evidence
|gene=DARC
|aa_change=Gly44Asp
|aa_change_short=G44D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12075
|overall_frequency_n=71
|overall_frequency_d=128
|overall_frequency=0.554688
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|nblosum100=4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24260134
|Title=Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}