{{Rsnum
|rsid=12097901
|Chromosome=1
|Orientation=plus
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene=EGLN1
|position=231421509
|Gene_s=EGLN1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs12097901]], also known as c.380G>C or Cys127Ser, is a SNP in the [[EGLN1]] egl-9 family hypoxia-inducible factor 1 gene. The [[EGLN1]] gene encodes prolyl hydroxylase 2 (PHD2) protein.

Along with another SNP seen frequently primarily in Tibetans, [[rs186996510]], this SNP is reported to have arisen ~8,000 years ago as an adaptation protecting Tibetans from [[hypoxia]] at the high altitudes they inhabit.{{PMID|25129147}}