{{Rsnum
|rsid=12130333
|Chromosome=1
|position=62726106
|Orientation=plus
|GMAF=0.1185
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 61.6 | 32.1 | 6.2
| HCB | 96.4 | 3.6 | 0.0
| JPT | 97.3 | 2.7 | 0.0
| YRI | 91.8 | 8.2 | 0.0
| ASW | 71.9 | 26.3 | 1.8
| CHB | 96.4 | 3.6 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 75.2 | 21.8 | 3.0
| LWK | 89.1 | 10.9 | 0.0
| MEX | 67.2 | 20.7 | 12.1
| MKK | 75.0 | 21.8 | 3.2
| TSI | 67.6 | 27.5 | 4.9
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs12130333
|PubMedID=18193044
|Condition=Triglycerides
|Gene=ANGPTL3, DOCK7, ATG4C
|Risk Allele=C
|pValue=2.00E-008
|OR=0.11
|95CI=0.07-0.15) % SD lowe
|OA=1
}}

{{PharmGKB
|RSID=rs12130333
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18193044; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Initial Sample Size: 2,758 individuals; Replication Sample Size: 18,544 individuals; Risk Allele: rs12130333-C). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356715
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by [[hypertriglyceridemia]]
|OA=1
}}

{{PMID|18596051}} Polygenic determinants of severe hypertriglyceridemia.

{{PMID|19060910|OA=1
}} Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

{{PMID|19197348|OA=1
}} Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

{{PMID|19802338|OA=1
}} Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

{{PMID|21691831}} Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12130333
|overall_frequency_n=23
|overall_frequency_d=128
|overall_frequency=0.179688
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22896670
|Title=Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}