{{Rsnum
|rsid=121908287
|Gene=FIG4
|Chromosome=6
|position=109715133
|Orientation=plus
|GMAF=0.0009183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FIG4
}}[[rs121908287]], also known as I41T, is a SNP in the [[FIG4]] gene that encodes a variation for an amino acid that is normally conserved in many species (from yeast to humans). The common allele is [[rs121908287]](T), encoding the isoleucine at this position; the very rare [[rs121908287]](C) encodes a threonine.

[[rs121908287]](C) apparently gives rise to a partial loss of function that is pathogenic in combination with a null allele of FIG4, leading these compound heterozygotes to [[Charcot-Marie-Tooth]] disease, Type 4J ([http://www.ncbi.nlm.nih.gov/omim/611228 OMIM 611228]).{{PMID|17572665|OA=1
}}
{{omim
|id=609390
|rsnum=121908287
|variant=0001
}}{{ClinVar
|rsid=121908287
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=110036336
|CHROM=6
|GMAF=0.0009
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050160000000040016110100
|GENEINFO=FIG4:9896
|GENE_NAME=FIG4
|GENE_ID=9896
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.110036336T>C
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NBK1468; 609390.0001
|CLNSIG=5
|CLNCUI=C1970011
|CLNDBN=Charcot-Marie-Tooth disease, type 4J
|Disease=Charcot-Marie-Tooth disease
|CLNACC=RCV000001791.1
|Tags=PM;SLO;VLD;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9991; 0.0009183
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1468:C1970011:611228:139515
|COMMON=0
}}