{{Rsnum
|rsid=121908377
|Chromosome=7
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=FOXP2
|position=114662075
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=FOXP2
}}

[[rs121908377]], also known as Arg553His or R553H, is a G-to-A transition in exon 14 of the [[FOXP2]] gene. 

As a dominant mutation, [[rs121908377]](G) has been linked to developmental verbal dyspraxia.{{PMID|11586359}} The associated disorder is known as Speech-language disorder-1 or SPCH1.



{{omim
|id=605317
|rsnum=121908377
|variant=0001
}}{{ClinVar
|rsid=121908377
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=114302130
|CHROM=7
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050260000000000002110100
|GENEINFO=FOXP2:93986
|GENE_NAME=FOXP2
|GENE_ID=93986
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.114302130G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=605317.0001
|CLNSIG=5
|CLNCUI=CN032592
|CLNDBN=Speech-language disorder 1
|Disease=Speech-language disorder 1
|CLNACC=RCV000005371.2
|Tags=PM;S3D;OTHERKG;LSD;OM
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=CN032592:602081:209908
}}