{{Rsnum
|rsid=121918592
|Chromosome=19
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=RYR1
|position=38448712
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=121918592
|variant=0006
}}{{ClinVar
|rsid=121918592
|Reversed=0
|FwdREF=G
|FwdALT=A,C
|REF=G
|ALT=A,C
|RSPOS=38939352
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38939352G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=180901.0006
|CLNSIG=255
|CLNCUI=C0024591
|CLNDBN=Malignant hyperthermia
|Disease=Malignant hyperthermia
|CLNACC=RCV000013836.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1146:C0024591:145600:423
}}

[[rs121918592]], aka p.Gly341Arg or p.G341R, is a SNP in the [[RYR1]] gene leading to increased susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID Auto
|PMID=12059893
|Title=Mutation screening in the ryanodine receptor 1 gene (RYR1) in patients susceptible to malignant hyperthermia who show definite IVCT results: identification of three novel mutations.
}}

{{PMID Auto
|PMID=12434264
|Title=[Current aspects of the diagnosis of malignant hyperthermia].
}}

{{PMID Auto
|PMID=16917943
|Title=Mutations in RYR1 in malignant hyperthermia and central core disease.
}}

{{PMID Auto
|PMID=18564801
|Title=Identification of genetic mutations in Australian malignant hyperthermia families using sequencing of RYR1 hotspots.
}}

{{PMID Auto
|PMID=16732084
|Title=Malignant hyperthermia in Japan: mutation screening of the entire ryanodine receptor type 1 gene coding region by direct sequencing.
}}