{{Rsnum
|rsid=121918593
|Chromosome=19
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=RYR1
|position=38499993
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=121918593
|variant=0007
}}{{ClinVar
|rsid=121918593
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=38990633
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38990633G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=180901.0007
|CLNSIG=255
|CLNCUI=C0024591
|CLNDBN=Malignant hyperthermia
|Disease=Malignant hyperthermia
|CLNACC=RCV000013837.1
|Tags=PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1146:C0024591:145600:423
}}

[[rs121918593]], aka p.Gly2434Arg or p.G2434R, is a SNP in the [[RYR1]] gene leading to susceptibility to [[malignant hyperthermia]] when heterozygous.

{{PMID Auto
|PMID=9030597
|Title=Functional characterization of a distinct ryanodine receptor mutation in human malignant hyperthermia-susceptible muscle.
}}