{{Rsnum
|rsid=12191877
|Chromosome=6
|position=31285148
|Orientation=plus
|GMAF=0.107
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 76.1 | 21.2 | 2.7
| HCB | 81.8 | 17.5 | 0.7
| JPT | 97.3 | 2.7 | 0.0
| YRI | 97.3 | 2.7 | 0.0
| ASW | 80.7 | 19.3 | 0.0
| CHB | 81.8 | 17.5 | 0.7
| CHD | 81.7 | 18.3 | 0.0
| GIH | 49.5 | 41.6 | 8.9
| LWK | 65.5 | 33.6 | 0.9
| MEX | 79.3 | 20.7 | 0.0
| MKK | 64.1 | 32.7 | 3.2
| TSI | 63.7 | 31.4 | 4.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19169254
|Trait=Psoriasis
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|RiskAllele=T
|Pval=1E-100
|OR=2.64
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19680446
|Title=Multiple Loci within the major histocompatibility complex confer risk of psoriasis
|OA=1
}}

{{PharmGKB
|RSID=rs12191877
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 6p21.33; Reported Gene(s): HLA-C; Risk Allele: rs12191877-T); (p-value= 1E-100).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740039
}}

{{PMID Auto GWAS
|PMID=20953188
|Trait=None
|Title=Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
|RiskAllele=
|Pval=4E-32
|OR=2.7900
|ORtxt=[2.35-3.33] (Panel A)
|OA=1
}}

{{PMID|19262574|OA=1
}} Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.

{{PMID|20606885|OA=1
}} Genetics of psoriasis and psoriatic arthritis.

{{PMID|21214922|OA=1
}} Psoriasis prediction from genome-wide SNP profiles.

{{PMID|21304891|OA=1
}} A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12191877
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24566688
|Title=Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients
}}

{{PMID Auto
|PMID=24566686
|Title=Human leukocyte antigen (HLA)-C polymorphisms are associated with a decreased risk of rheumatoid arthritis
}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}