{{Rsnum
|rsid=12212067
|Gene=FOXO3
|Chromosome=6
|position=108659993
|Orientation=plus
|GMAF=0.1336
|Gene_s=FOXO3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}[[rs12212067]] is a noncoding SNP in the [[FOXO3A]] gene.  This gene encodes the FOXO3 protein, a member of the forkhead box O family of transcription factors. These proteins are expressed in many cell types, with roles in cell-cycle control, metabolism, regulatory T cell development and apoptosis. It's role in cytokine production appears to be the key factor in this SNP's association with disease prognosis (but, interestingly, no role in disease susceptibility has been found to date).

[[rs12212067]](G), the minor allele, is connected to the downregulation of TNF and several other proinflammatory cytokines in response to various antigens, and, the upregulation of IL10, a cytokine associated with anti-inflammatory effects. As elucidated in the cited study, this appears to explain the better outcomes for [[rs12212067]](G) carriers of treatment for two auto-immune disorders, [[rheumatoid arthritis]] and [[Crohn's disease]]. As might be predicted for an infectious disease relying on an upregulated inflammatory response (which isn't happening as much with these carriers), this also leads to worse outcomes for carriers afflicted with [[malaria]].{{PMID|24035192|OA=1
}};{{PMID|24074853}} 

{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.9 | 14.3 | 84.8
| HCB | 2.2 | 15.4 | 82.4
| JPT | 0.9 | 19.5 | 79.6
| YRI | 4.8 | 31.3 | 63.9
| ASW | 7.0 | 24.6 | 68.4
| CHB | 2.2 | 15.4 | 82.4
| CHD | 3.8 | 22.9 | 73.3
| GIH | 1.0 | 16.2 | 82.8
| LWK | 6.4 | 36.7 | 56.9
| MEX | 0.0 | 0.0 | 0.0
| MKK | 7.2 | 37.5 | 55.3
| TSI | 3.0 | 22.0 | 75.0
| HapMapRevision=28
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}