{{Rsnum
|rsid=12243326
|Gene=TCF7L2
|Chromosome=10
|position=114788815
|Orientation=plus
|GMAF=0.1974
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 29.2 | 61.1
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.9 | 4.4 | 94.7
| YRI | 8.2 | 42.9 | 49.0
| ASW | 7.0 | 40.4 | 52.6
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 1.9 | 98.1
| GIH | 4.0 | 38.6 | 57.4
| LWK | 6.4 | 32.7 | 60.9
| MEX | 3.4 | 37.9 | 58.6
| MKK | 3.8 | 35.3 | 60.9
| TSI | 11.8 | 36.3 | 52.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20081857
|Trait=Two-hour glucose challenge
|Title=Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
|RiskAllele=C
|Pval=1E-7
|OR=0.08
|ORtxt=[0.06-0.10] mmol/L increase
|OA=1
}}

{{PharmGKB
|RSID=rs12243326
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:20081857
|Annotation=Risk or phenotype-associated allele: C . Phenotype: In a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620), this SNP was found to be associated with 2-h glucose level (a clinical measure of glucose tolerance). Effect (s.e.m.) = 0.08(0.01) mmol/l per C allele. Study size/population/ethnicity: 15,234 plus 6,958-30,620 nondiabetic individuals of European descent. Significance metric(s): p = 4.23 x 10(-10). Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281984
}}

{{PMID Auto
|PMID=17934151
|Title=A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12243326
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24157263
|Title=Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)
}}

{{PMID Auto
|PMID=23107111
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
}}

{{PMID Auto
|PMID=23142382
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}