{{Rsnum
|rsid=12255372
|Gene=TCF7L2
|Chromosome=10
|position=113049143
|Orientation=plus
|GMAF=0.2029
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Associated with T2D, breast and prostate cancers.
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TCF7L2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 60.2 | 30.1 | 9.7
| HCB | 100.0 | 0.0 | 0.0
| JPT | 94.7 | 4.4 | 0.9
| YRI | 48.3 | 42.9 | 8.8
| ASW | 49.1 | 43.9 | 7.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 56.4 | 39.6 | 4.0
| LWK | 59.1 | 35.5 | 5.5
| MEX | 58.6 | 37.9 | 3.4
| MKK | 78.8 | 19.9 | 1.3
| TSI | 48.0 | 40.2 | 11.8
| HapMapRevision=28
}}This [[SNP]] is in the [[TCF7L2]] gene, and has been linked to [[type-2 diabetes]], [[breast cancer]] and aggressive [[prostate cancer]]. This SNP is also known as IVS4G>T.

{{PMID|17109766|OA=1
}} is the paper which links it to [[Breast cancer]]. It suggests the T allele as increasing risk.

{{PMID|16936217}} reports the association of [[rs12255372]] and [[rs7903146]] with [[Type-2 diabetes]] in a Finnish sample.

[[rs12255372]] Common variants (rs12255372 and rs7903146) in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance

{{PMID|17671651|OA=1
}} Considered for [[type-2 diabetes]] with [[rs7903146]] [[rs12255372]] [[rs10885406]]. 

{{PMID|17971425|OA=1
}} Associated in a study of ~1000 Hispanic-Americans with reduced insulin secretion as measured by acute insulin response and adjusted for the degree of insulin sensitivity (p = 0.036).

{{PMID|18302196|OA=1
}} In a study of 1,457 [[prostate cancer]] cases and 1,351 controls, while there was no association with overall risk, males who were [[rs12255372]](T;T) homozygotes and who had prostate cancer were at elevated relative risk of more aggressive [[prostate cancer]], as defined by high Gleason score (OR = 1.7, CI: 1.0-2.8) or regional/distant stage (OR = 1.7, CI: 1.1-2.6) disease.

{{PMID|19033397|OA=1
}} This SNP was confirmed to be associated with [[type-2 diabetes]] in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

A HuGE review and meta-analysis including over 35,000 [[type-2 diabetes]] cases and 39,000 controls concluded that the Bayesian odds ratio for [[rs12255372]](T;T) homozygotes and (G;T) heterozygotes versus (G;G) homozygotes was 1.885 (95% credible interval (CrI): 1.698 - 2.088) and 1.360 (95% CrI: 1.291 - 1.433), respectively. Along with 3 other [[TCF7L2]] SNPs, a multiplicative genetic model was indicated.{{PMID|19228405|OA=1
}}

{{PMID Auto
|PMID=18972257
|Title=Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study
}}

{{PMID Auto
|PMID=19183934
|Title=TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study
|OA=1
}}

{{omim
|id=602228
|desc=TRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
|rsnum=12255372
}}
{{PMID Auto
|PMID=19732438
|Title=No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
|OA=1
}}

{{PharmGKB
|RSID=rs12255372
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:17519421
|Annotation=The variant in the intronic region of TCF7L2 was found to substantially contribute to the risk of type 2 diabetes. The TCF7L2 variant influences therapeutic response to sulfonylureas but not metformin.
|Drugs=
|Drug Classes=SULFONAMIDES, UREA DERIVATIVES
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161660934
}}
{{PMID Auto
|PMID=20028944
|Title=Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=20361036
|Title=Gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population
|OA=1
}}
{{PMID Auto
|PMID=20503258
|Title=Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
}}
{{PMID Auto
|PMID=20546291
|Title=Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5)
}}

{{PMID Auto
|PMID=21301999
|Title=Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters
}}

{{omim
|id=602228
|rsnum=12255372
|variant=0002
}}

{{PMID Auto
|PMID=21109996
|Title=Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth
|OA=1
}}

{{PMID Auto
|PMID=22052079
|Title=Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
|OA=1
}}

{{PMID Auto
|PMID=22402060
|Title=Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22441719
|Title=Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
}}

{{PMID Auto
|PMID=17437080
|Title=Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
}}

{{PMID Auto
|PMID=21399856
|Title=Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians
}}

{{PMID Auto
|PMID=16855264
|Title=TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
|OA=1
}}

{{PMID Auto
|PMID=16936216
|Title=Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.
}}

{{PMID Auto
|PMID=16936218
|Title=Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
}}

{{PMID Auto
|PMID=17003360
|Title=Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
}}

{{PMID Auto
|PMID=17031610
|Title=Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
}}

{{PMID Auto
|PMID=17093941
|Title=Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
}}

{{PMID Auto
|PMID=17130514
|Title=Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.
}}

{{PMID Auto
|PMID=17226113
|Title=Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys.
}}

{{PMID Auto
|PMID=17245407
|Title=TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.
}}

{{PMID Auto
|PMID=17245589
|Title=A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=17259383
|Title=Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.
}}

{{PMID Auto
|PMID=17317761
|Title=Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.
|OA=1
}}

{{PMID Auto
|PMID=17340123
|Title=Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.
}}

{{PMID Auto
|PMID=17429603
|Title=TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
}}

{{PMID Auto
|PMID=17463248
|Title=A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|OA=1
}}

{{PMID Auto
|PMID=17470138
|Title=Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.
}}

{{PMID Auto
|PMID=17503332
|Title=Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
|OA=1
}}

{{PMID Auto
|PMID=17579206
|Title=Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.
}}

{{PMID Auto
|PMID=17601994
|Title=Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
}}

{{PMID Auto
|PMID=17618413
|Title=Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.
}}

{{PMID Auto
|PMID=17661009
|Title=Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=17665514
|Title=Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.
}}

{{PMID Auto
|PMID=17668382
|Title=Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|OA=1
}}

{{PMID Auto
|PMID=17697858
|Title=The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.
}}

{{PMID Auto
|PMID=17805508
|Title=Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.
}}

{{PMID Auto
|PMID=17903298
|Title=Genome-wide association with diabetes-related traits in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=17909099
|Title=TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals.
}}

{{PMID Auto
|PMID=17934151
|Title=A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
}}

{{PMID Auto
|PMID=17972059
|Title=TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.
}}

{{PMID Auto
|PMID=18097733
|Title=Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=18268068
|Title=Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.
|OA=1
}}

{{PMID Auto
|PMID=18282631
|Title=Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.
}}

{{PMID Auto
|PMID=18291022
|Title=Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=18437354
|Title=TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.
|OA=1
}}

{{PMID Auto
|PMID=18478343
|Title=Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.
|OA=1
}}

{{PMID Auto
|PMID=18493736
|Title=Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population.
}}

{{PMID Auto
|PMID=18598350
|Title=Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
|OA=1
}}

{{PMID Auto
|PMID=18650481
|Title=TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
|OA=1
}}

{{PMID Auto
|PMID=18655717
|Title=Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
|OA=1
}}

{{PMID Auto
|PMID=18706099
|Title=TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18712344
|Title=Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.
}}

{{PMID Auto
|PMID=19002430
|Title=Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
}}

{{PMID Auto
|PMID=19050058
|Title=Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19053027
|Title=Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.
}}

{{PMID Auto
|PMID=19141698
|Title=Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia.
|OA=1
}}

{{PMID Auto
|PMID=19211816
|Title=TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women.
|OA=1
}}

{{PMID Auto
|PMID=19279076
|Title=Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.
|OA=1
}}

{{PMID Auto
|PMID=19309528
|Title=Specific and complete human genome amplification with improved yield achieved by phi29 DNA polymerase and a novel primer at elevated temperature.
|OA=1
}}

{{PMID Auto
|PMID=19351735
|Title=Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.
|OA=1
}}

{{PMID Auto
|PMID=19369405
|Title=Linkage analysis of albuminuria.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19482368
|Title=Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
}}

{{PMID Auto
|PMID=19497595
|Title=Genetic variation of FTO and TCF7L2 in premature adrenarche.
}}

{{PMID Auto
|PMID=19602480
|Title=Tissue-specific alternative splicing of TCF7L2.
|OA=1
}}

{{PMID Auto
|PMID=19789636
|Title=Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19825152
|Title=TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.
|OA=1
}}

{{PMID Auto
|PMID=19924244
|Title=TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.
|OA=1
}}

{{PMID Auto
|PMID=20075150
|Title=Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=20161033
|Title=Personalized pharmacotherapy for Type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20648057
|Title=Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.
|OA=1
}}

{{PMID Auto
|PMID=21159844
|Title=Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21349175
|Title=TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21423583
|Title=Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=21441683
|Title=Screening with OGTT alone or in combination with the Indian diabetes risk score or genotyping of TCF7L2 to detect undiagnosed type 2 diabetes in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=21672010
|Title=Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=21834909
|Title=A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.
}}

{{PMID Auto
|PMID=21898192
|Title=Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.
}}

{{PMID Auto
|PMID=22301903
|Title=Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS.
|OA=1
}}

{{PMID Auto
|PMID=23041303
|Title=Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12255372
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|autoscore=1
|webscore=N
|summary_short=response to a drug sulfonylurea in diabetes 
}}

{{PMID Auto
|PMID=23577093
|Title=Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India
|OA=1
}}

{{PMID Auto
|PMID=23579632
|Title=Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=23690305
|Title=Genetic variants and the risk of gestational diabetes mellitus: a systematic review
}}

{{PMID Auto
|PMID=23188737
|Title=TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
}}

{{PMID Auto
|PMID=24157263
|Title=Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)
}}

{{PMID Auto
|PMID=24371822
|Title=IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
|OA=1
}}

{{PMID Auto
|PMID=22480428
|Title=T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.
}}

{{PMID Auto
|PMID=22843023
|Title=TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.
}}

{{PMID Auto
|PMID=23034957
|Title=TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.
|OA=1
}}

{{PMID Auto
|PMID=23085767
|Title=Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
|OA=1
}}

{{PMID Auto
|PMID=23107111
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
}}

{{PMID Auto
|PMID=23142382
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.
}}

{{PMID Auto
|PMID=25185411
|Title=Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish ethnic group
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}