{{Rsnum
|rsid=12272004
|Chromosome=11
|position=116733008
|Orientation=plus
|GMAF=0.07576
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 7.1 | 92.9
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 2.7 | 29.3 | 68.0
| ASW | 0.0 | 15.8 | 84.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 6.9 | 93.1
| LWK | 2.8 | 24.5 | 72.6
| MEX | 3.4 | 20.7 | 75.9
| MKK | 1.3 | 25.7 | 73.0
| TSI | 4.0 | 10.9 | 85.1
| HapMapRevision=28
}}{{PMID|19185284|OA=1
}} [[rs12272004]] associated with alpha-tocopherol (meta-analysis p = 7.8 x 10(-10)) levels; the association was substantially weaker when adjusted for triglyceride levels (p = 0.002).

{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=C
|Pval=7E-7
|OR=0.11
|ORtxt=[NR] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs12272004
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,797 individuals; Replication Sample Size: NR); (Region: 11q23.3; Reported Gene(s): APOA1, APOA4, APOA5, APOC3; Risk Allele: rs12272004-C); (p-value= 0.0000000000005).This variant is associated with LDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740214
}}

{{PharmGKB
|RSID=rs12272004
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19185284; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. (Initial Sample Size: 1,191 individuals; Replication Sample Size: 2,751 individuals); (Region: 11q23.3; Reported Gene(s): APOA5; Risk Allele: rs12272004-A); (p-value= 0.0000000008).This variant is associated with Plasma carotenoid and tocopherol levels.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740023
}}

{{PharmGKB
|RSID=rs12272004
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 11q23.3; Reported Gene(s): APOA1, APOA4, APOA5, APOC3; Risk Allele: rs12272004-C); (p-value= 0.0000007).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740191
}}

{{PharmGKB
|RSID=rs12272004
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,815 individuals; Replication Sample Size: NR); (Region: 11q23.3; Reported Gene(s): APOA1, APOA4, APOA5, APOC3; Risk Allele: rs12272004-C); (p-value= 0.0000000000005).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740226
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12272004
|overall_frequency_n=9
|overall_frequency_d=128
|overall_frequency=0.0703125
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23452379
|Title=APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}