{{Rsnum
|rsid=12273539
|Gene=BDNF
|Chromosome=11
|position=27661764
|Orientation=plus
|GMAF=0.1419
|Gene_s=BDNF,BDNF-AS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 70.1 | 27.7 | 2.2
| JPT | 67.3 | 28.3 | 4.4
| YRI | 37.4 | 50.3 | 12.2
| ASW | 54.4 | 43.9 | 1.8
| CHB | 70.1 | 27.7 | 2.2
| CHD | 65.1 | 33.9 | 0.9
| GIH | 96.0 | 4.0 | 0.0
| LWK | 58.2 | 30.9 | 10.9
| MEX | 53.4 | 41.4 | 5.2
| MKK | 65.4 | 32.1 | 2.6
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs12273539
|Name_s=
|Gene_s=BDNF
|Feature=
|Evidence=PubMed ID:19414708
|Annotation=This intronic variant (T/C) in the BDNF gene was associated with major depressive disorder in a study of 264 controls and 272 Mexican Americans with major depressive disorder. (OR= 1.75; p value=<0.001; risk allele=T)
|Drugs=
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA164857049
}}

{{PMID Auto
|PMID=19721723
|Title=Brain-derived neurotrophic factor: role in depression and suicide.
|OA=1
}}

{{PMID Auto
|PMID=20193311
|Title=[Association between polymorphism of BDNF and internalizing disorders.].
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12273539
|overall_frequency_n=22
|overall_frequency_d=128
|overall_frequency=0.171875
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23832605
|Title=Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}