{{Rsnum
|rsid=12284594
|Gene=PKNOX2
|Chromosome=11
|position=125309957
|Orientation=plus
|GMAF=0.2938
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PKNOX2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 74.3 | 22.1 | 3.5
| HCB | 21.9 | 50.4 | 27.7
| JPT | 21.2 | 53.1 | 25.7
| YRI | 35.6 | 49.3 | 15.1
| ASW | 56.1 | 35.1 | 8.8
| CHB | 21.9 | 50.4 | 27.7
| CHD | 24.8 | 46.8 | 28.4
| GIH | 51.5 | 39.6 | 8.9
| LWK | 44.5 | 40.0 | 15.5
| MEX | 81.0 | 19.0 | 0.0
| MKK | 59.0 | 38.5 | 2.6
| TSI | 66.7 | 32.4 | 1.0
| HapMapRevision=28
}}[http://blog.23andme.com/2009/09/01/snpwatch-genetic-variation-associated-with-addiction-in-caucasian-women/ 23andMe blog] In white women, each G increased risk of multiple addictions 1.77x

{{PMID Auto GWAS
|PMID=21298047
|Trait=None
|Title=The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
|RiskAllele=G
|Pval=7E-8
|OR=1.7700
|ORtxt=None
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}