{{Rsnum
|rsid=12286037
|Gene=ZNF259
|Chromosome=11
|position=116781491
|Orientation=plus
|GMAF=0.08861
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ZPR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 92.0 | 8.0 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 64.6 | 32.0 | 3.4
| ASW | 70.2 | 28.1 | 1.8
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 94.1 | 5.9 | 0.0
| LWK | 57.3 | 38.2 | 4.5
| MEX | 80.7 | 19.3 | 0.0
| MKK | 66.0 | 32.1 | 1.9
| TSI | 86.3 | 10.8 | 2.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18193043
|Trait=Triglycerides
|Title=Newly identified loci that influence lipid concentrations and risk of coronary artery disease
|RiskAllele=T
|Pval=1E-26
|OR=25.82
|ORtxt=[NR] mg/dl higher
}}

{{PMID Auto GWAS
|PMID=20442857
|Trait=Lipoprotein-associated phospholipase A2 activity and mass
|Title=Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study
|RiskAllele=T
|Pval=4E-8
|OR=6.40
|ORtxt=[NR] nmol/ml/min increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=21386085
|Trait=None
|Title=A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
|RiskAllele=C
|Pval=1E-8
|OR=0.3200
|ORtxt=[0.20-0.44] unit decrease
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12286037
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}