{{Rsnum
|rsid=1230345
|Gene=WISP3
|Chromosome=6
|position=112061110
|Orientation=minus
|GMAF=0.3003
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=WISP3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 4.4 | 37.2 | 58.4
| HCB | 12.4 | 43.1 | 44.5
| JPT | 7.1 | 36.3 | 56.6
| YRI | 22.4 | 48.3 | 29.3
| ASW | 12.3 | 66.7 | 21.1
| CHB | 12.4 | 43.1 | 44.5
| CHD | 8.3 | 44.0 | 47.7
| GIH | 2.0 | 25.7 | 72.3
| LWK | 22.7 | 41.8 | 35.5
| MEX | 6.9 | 39.7 | 53.4
| MKK | 19.9 | 44.2 | 35.9
| TSI | 4.9 | 44.1 | 51.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=1230345
|allele=T
|frequency=0.225
|uid=1103652968863
|type=heterozygous_SNP
|hugo=WISP3
|ensembl gene=ENSG00000112761
|ensembl transcript=ENST00000321123
|sift=TOLERATED
|disease=Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC) (MIM:208230). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.
}}

{{ neighbor
| rsid = 17073260
| distance = 10
}}

{{GET Evidence
|gene=WISP3
|aa_change=Gln74His
|aa_change_short=Q74H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1230345
|overall_frequency_n=3599
|overall_frequency_d=10758
|overall_frequency=0.334542
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}