{{Rsnum
|rsid=12304921
|Gene=HIGD1C
|Chromosome=12
|position=50963759
|Orientation=plus
|GMAF=0.2369
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HIGD1C
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 70.8 | 27.4 | 1.8
| HCB | 27.0 | 46.0 | 27.0
| JPT | 25.7 | 54.0 | 20.4
| YRI | 74.7 | 21.2 | 4.1
| ASW | 60.0 | 36.4 | 3.6
| CHB | 27.0 | 46.0 | 27.0
| CHD | 23.9 | 52.3 | 23.9
| GIH | 38.6 | 50.5 | 10.9
| LWK | 59.8 | 38.3 | 1.9
| MEX | 75.9 | 24.1 | 0.0
| MKK | 60.9 | 30.1 | 9.0
| TSI | 81.0 | 18.0 | 1.0
| HapMapRevision=28
}}
[[rs12304921]] has been reported in a large study to be associated with [[type-2 diabetes]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 2.50 (CI 1.53-4.09), and for homozygotes, 1.94 (CI 1.20-3.15). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs12304921
|PubMedID=17554300
|Condition=Type 2 diabetes
|Gene=NR
|Risk Allele=G
|pValue=7.00E-006
|OR=2.5
|95CI=1.53-4.09
|OA=1
}}

{{PharmGKB
|RSID=rs12304921
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: (see Zeggini 2007); Risk Allele: rs12304921-G). This variant is associated with type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356640
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12304921
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}