{{Rsnum
|rsid=12364283
|Gene=DRD2
|Chromosome=11
|position=113476233
|Orientation=plus
|GMAF=0.03627
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DRD2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 84.1 | 15.0 | 0.9
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 98.6 | 1.4 | 0.0
| ASW | 91.2 | 8.8 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 69.3 | 30.7 | 0.0
| LWK | 96.4 | 3.6 | 0.0
| MEX | 93.1 | 6.9 | 0.0
| MKK | 89.7 | 10.3 | 0.0
| TSI | 78.4 | 20.6 | 1.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19373123
|Title=Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
}}

{{PharmGKB
|RSID=rs12364283
|Name_s=
|Gene_s=DRD2
|Feature=
|Evidence=PubMed ID:18077373; PubMed ID:18829695
|Annotation=This promoter variant affects total DRD2 mRNA expression. The C allele is associated with enhanced total DRD2 mRNA expression and is associated with working memory activity in prefrontal cortex and striatum of schizophrenia patients.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162355756
}}

{{PMID Auto
|PMID=19512960
|Title=Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
}}
{{PMID Auto
|PMID=19968402
|Title=Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
|OA=1
}}

{{PMID Auto
|PMID=19393722
|Title=Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12364283
|overall_frequency_n=6
|overall_frequency_d=128
|overall_frequency=0.046875
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23647975
|Title=PTSD risk associated with a functional DRD2 polymorphism in heroin-dependent cases and controls is limited to amphetamine-dependent individuals
}}

{{PMID Auto
|PMID=22579533
|Title=Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}