{{Rsnum
|rsid=12422149
|Gene=SLCO2B1
|Chromosome=11
|position=75172532
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2016
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SLCO2B1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 20.4 | 79.6
| HCB | 16.1 | 44.5 | 39.4
| JPT | 11.5 | 51.3 | 37.2
| YRI | 0.0 | 13.6 | 86.4
| ASW | 7.0 | 17.5 | 75.4
| CHB | 16.1 | 44.5 | 39.4
| CHD | 8.3 | 51.4 | 40.4
| GIH | 10.9 | 37.6 | 51.5
| LWK | 2.7 | 22.7 | 74.5
| MEX | 17.2 | 39.7 | 43.1
| MKK | 0.6 | 25.0 | 74.4
| TSI | 1.0 | 16.7 | 82.4
| HapMapRevision=28
}}
{{PMID|19151602|OA=1
}} rs12422149 linked to [[asthma]]

{{PharmGKB
|RSID=rs12422149
|Name_s=SLCO2B1:G935A, SLCO2B1:Arg312Gln
|Gene_s=SLCO2B1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19151602
|Annotation=In an 80-patient study, the A allele of this variant was associated with significantly reduced plasma concentrations of montelukast and with poor response to treatment with montelukast.
|Drugs=montelukast
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162928868
}}

{{PMID Auto
|PMID=21266523
|Title=Expression of SLCO transport genes in castration resistant prostate cancer and impact of genetic variation in SCLO1B3 and SLCO2B1 on prostate cancer outcomes
|OA=1
}}

{{PMID Auto
|PMID=19077707
|Title=Pharmacogenetics of asthma.
|OA=1
}}

{{PMID Auto
|PMID=19665766
|Title=Genetics and pharmacogenetics of the leukotriene pathway.
|OA=1
}}

{{PMID Auto
|PMID=20974993
|Title=Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast.
}}

{{GET Evidence
|gene=SLCO2B1
|aa_change=Arg312Gln
|aa_change_short=R312Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12422149
|overall_frequency_n=1036
|overall_frequency_d=10758
|overall_frequency=0.0963004
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.006
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23151832
|Title=SLCO2B1 c.935G&gt;A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren
}}

{{PMID Auto
|PMID=23666051
|Title=SLCO2B1 genetic polymorphisms in a Korean population: pyrosequencing analyses and comprehensive comparison with other populations.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}