{{Rsnum
|rsid=12425791
|Gene=NINJ2
|Chromosome=12
|position=674318
|Orientation=plus
|GMAF=0.2016
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 30.1 | 67.3
| HCB | 6.6 | 31.4 | 62.0
| JPT | 8.8 | 47.8 | 43.4
| YRI | 1.4 | 17.0 | 81.6
| ASW | 0.0 | 17.5 | 82.5
| CHB | 6.6 | 31.4 | 62.0
| CHD | 4.6 | 38.5 | 56.9
| GIH | 9.9 | 37.6 | 52.5
| LWK | 0.9 | 11.8 | 87.3
| MEX | 12.1 | 53.4 | 34.5
| MKK | 1.9 | 16.7 | 81.4
| TSI | 7.8 | 37.3 | 54.9
| HapMapRevision=28
}}[[rs12425791]] is one of 2 SNPs found near the [[NINJ2]] gene on chromosome 12 associated with increased risk for both total stroke and ischemic [[stroke]], based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is [[rs11833579]].

Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. {{PMID|19369658|OA=1
}}

Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either [[rs12425791]] or [[rs11833579]] and ischemic (or incident) stroke.[http://content.nejm.org/cgi/content/short/362/16/1547]

{{PMID Auto GWAS
|PMID=19369658
|Trait=Stroke
|Title=Genomewide Association Studies of Stroke
|Strongest=rs12425791
|RiskAllele=A
|Pval=1E-9
|OA=1
}}

{{PharmGKB
|RSID=rs12425791
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19369658; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genomewide Association Studies of Stroke. (Initial Sample Size: 19,602 Caucasian individuals; Replication Sample Size: 3,004 African American individuals, 652 Caucasian cases, 3,613 Caucasian controls); (Region: 12p13.33; Reported Gene(s): NINJ2; Risk Allele: rs12425791-A); (p-value= 0.000000001).This variant is associated with Stroke.
|Drugs=
|Drug Classes=
|Diseases=Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739855
}}

{{PharmGKB
|RSID=rs12425791
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19369658
|Annotation=This variant within 11 kb of the gene NINJ2 were associated with an increased risk of total (i.e., all types) and ischemic stroke. NINJ2 encodes an adhesion molecule expressed in glia and shows increased expression after nerve injury.
|Drugs=
|Drug Classes=
|Diseases=Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA164738465
}}

{{omim
|id=601367
|rsnum=12425791
}}

{{PMID Auto
|PMID=21722921
|Title=NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
}}

{{PMID Auto
|PMID=21832970
|Title=Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
}}

{{PMID Auto
|PMID=22011019
|Title=Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
}}

{{PMID Auto
|PMID=22212150
|Title=Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
|OA=1
}}

{{PMID Auto
|PMID=22429733
|Title=NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
|OA=1
}}

{{PMID Auto
|PMID=20448654
|Title=Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
}}

{{PMID Auto
|PMID=21148441
|Title=Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.
}}

{{PMID Auto
|PMID=21376321
|Title=No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
}}

{{PMID Auto
|PMID=22297388
|Title=Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12425791
|overall_frequency_n=21
|overall_frequency_d=128
|overall_frequency=0.164062
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23270316
|Title=Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis
}}

{{PMID Auto
|PMID=23596786
|Title=[Correlation study on 12p13 single nucleotide polymorphism rs12425791 and Chinese medical syndrome types in ischemic stroke patients of the Han nationality]
}}

{{PMID Auto
|PMID=22938733
|Title=Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population
}}

{{PMID Auto
|PMID=22795341
|Title=The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}