{{Rsnum
|rsid=12467557
|Gene=NRXN1
|Chromosome=2
|position=51015132
|Orientation=plus
|GMAF=0.1915
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NRXN1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 90.6 | 9.4 | 0.0
| HCB | 41.9 | 46.5 | 11.6
| JPT | 42.2 | 42.2 | 15.6
| YRI | 81.0 | 19.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 41.9 | 46.5 | 11.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}rs12467557 increases susceptibility to Substance dependence, Nicotine 1.81 times for carriers of the C allele {{PMID|17158188|OA=1
}}

{{PMID Auto
|PMID=18270208
|Title=Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.
|OA=1
}}

{{PMID Auto
|PMID=20860064
|Title=Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | NatGeo2}}