{{Rsnum
|rsid=12474609
|Gene=LRP1B
|Chromosome=2
|position=140963573
|Orientation=plus
|GMAF=0.213
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=LRP1B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 72.3 | 27.7 | 0.0
| HCB | 61.3 | 34.3 | 4.4
| JPT | 38.1 | 46.0 | 15.9
| YRI | 63.0 | 32.2 | 4.8
| ASW | 55.4 | 42.9 | 1.8
| CHB | 61.3 | 34.3 | 4.4
| CHD | 64.8 | 31.5 | 3.7
| GIH | 57.1 | 34.7 | 8.2
| LWK | 52.8 | 42.6 | 4.6
| MEX | 57.9 | 40.4 | 1.8
| MKK | 54.8 | 39.4 | 5.8
| TSI | 65.0 | 34.0 | 1.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19367585
|Trait=Successful cognitive aging
|Title=A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis
|RiskAllele=
|Pval=6E-9
}}

{{PharmGKB
|RSID=rs12474609
|Name_s=
|Gene_s=LRP1B
|Feature=
|Evidence=PubMed ID:19367585; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis. (Initial Sample Size: 89 cases, 227 controls; Replication Sample Size: NR); (Region: 2q22.1; Reported Gene(s): LRP1B); (p-value= 0.000000006).This variant is associated with Successful cognitive aging.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739856
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12474609
|overall_frequency_n=10
|overall_frequency_d=94
|overall_frequency=0.106383
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}