{{Rsnum
|rsid=12485738
|Gene=ARHGEF3
|Chromosome=3
|position=56831748
|Orientation=plus
|GMAF=0.3659
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ARHGEF3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 18.6 | 41.6 | 39.8
| HCB | 21.9 | 43.8 | 34.3
| JPT | 14.2 | 47.8 | 38.1
| YRI | 7.5 | 38.1 | 54.4
| ASW | 7.0 | 52.6 | 40.4
| CHB | 21.9 | 43.8 | 34.3
| CHD | 16.5 | 44.0 | 39.4
| GIH | 18.0 | 51.0 | 31.0
| LWK | 9.1 | 50.9 | 40.0
| MEX | 29.3 | 56.9 | 13.8
| MKK | 13.5 | 43.6 | 42.9
| TSI | 18.6 | 39.2 | 42.2
| HapMapRevision=28
}}
{{PMID|19110211|OA=1
}} [[rs7961894]], [[rs12485738]] and [[rs2138852]] together accounted for 4%-5% of the variance in mean platelet volume, which is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality

{{omim
|desc=MEAN PLATELET VOLUME QUANTITATIVE TRAIT LOCUS 2; MPVQTL2
|id=612574
|rsnum=12485738
}}
{{PMID Auto GWAS
|PMID=19820697
|Trait=MPV
|Title=A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
|RiskAllele=A
|Pval=6E-31
|OR=0.02
|ORtxt=[0.013-0.017] fl increase
|OA=1
}}

{{PharmGKB
|RSID=rs12485738
|Name_s=
|Gene_s=ARHGEF3
|Feature=
|Evidence=PubMed ID:19110211
|Annotation=In replicated GWAS (three replication groups) of German and UK populations, this SNP was found to be strongly associated with Mean Platelet Volume. Combined N = 9,964; p= 3.81 x 10 ( -27).
|Drugs=
|Drug Classes=
|Diseases=Cerebral Infarction; Infarction; Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA164920504
}}

{{PharmGKB
|RSID=rs12485738
|Name_s=
|Gene_s=ARHGEF3
|Feature=
|Evidence=PubMed ID:19110211; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study identifies three loci associated with mean platelet volume. (Initial Sample Size: 1,606 individuals; Replication Sample Size: 8,617 individuals); (Region: 3p14.3; Reported Gene(s): ARHGEF3; Risk Allele: rs12485738-A); (p-value= 4E-27).This variant is associated with Mean platelet volume.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740100
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12485738
|overall_frequency_n=89
|overall_frequency_d=128
|overall_frequency=0.695312
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=81
|n_articles=1
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}