{{Rsnum
|rsid=12487066
|Gene=CBLB
|Chromosome=3
|position=106193283
|Orientation=plus
|GMAF=0.2612
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 45.1 | 45.1
| HCB | 5.1 | 36.8 | 58.1
| JPT | 8.0 | 42.9 | 49.1
| YRI | 6.1 | 32.0 | 61.9
| ASW | 5.3 | 42.1 | 52.6
| CHB | 5.1 | 36.8 | 58.1
| CHD | 6.4 | 32.1 | 61.5
| GIH | 14.9 | 50.5 | 34.7
| LWK | 14.5 | 40.9 | 44.5
| MEX | 3.4 | 56.9 | 39.7
| MKK | 12.2 | 48.1 | 39.7
| TSI | 3.9 | 31.4 | 64.7
| HapMapRevision=28
}}[[rs12487066]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with this allele is 1.09 (CI 1.03-1.16). {{PMID|17660530}}

{{PharmGKB
|RSID=rs12487066
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356172
}}

{{PMID Auto
|PMID=20007504
|Title=Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12487066
|overall_frequency_n=37
|overall_frequency_d=128
|overall_frequency=0.289062
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22492128
|Title=Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}