{{Rsnum
|rsid=12526453
|Gene=PHACTR1
|Chromosome=6
|position=12927312
|Orientation=plus
|GMAF=0.1905
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PHACTR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 42.5 | 41.6 | 15.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 97.3 | 2.7 | 0.0
| YRI | 78.9 | 19.7 | 1.4
| ASW | 80.7 | 17.5 | 1.8
| CHB | 100.0 | 0.0 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 76.2 | 21.8 | 2.0
| LWK | 84.5 | 14.5 | 0.9
| MEX | 53.4 | 34.5 | 12.1
| MKK | 73.5 | 24.5 | 1.9
| TSI | 44.1 | 41.2 | 14.7
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19198609
|Trait=Myocardial infarction (early onset)
|Title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
|RiskAllele=C
|Pval=1E-9
|OR=1.12
|ORtxt=[1.08-1.17]
|OA=1
}}

{{PharmGKB
|RSID=rs12526453
|Name_s=
|Gene_s=PHACTR1
|Feature=
|Evidence=PubMed ID:19198609; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (Initial Sample Size: 2,967 cases, 3,075 controls; Replication Sample Size: 9,746 cases, 9,746 controls); (Region: 6p24.1; Reported Gene(s): PHACTR1; Risk Allele: rs12526453-C); (p-value= 0.000000001).This variant is associated with Myocardial infarction (early onset).
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739969
}}

{{PharmGKB
|RSID=rs12526453
|Name_s=
|Gene_s=PHACTR1
|Feature=
|Evidence=PubMed ID:19198609
|Annotation=In a genome-wide association study this variant (rs12526453) in PHACTR1 was associated with with early-onset myocardial infarction in 2,967 cases and 3,075 controls.
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA162565798
}}

{{PMID Auto GWAS
|PMID=21378990
|Trait=None
|Title=Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
|RiskAllele=C
|Pval=1E-9
|OR=1.1000
|ORtxt=[1.06-1.13]
|OA=1
}}

{{PMID Auto
|PMID=22848412
|Title=Genetic Markers Enhance Coronary Risk Prediction in Men: The MORGAM Prospective Cohorts
|OA=1
}}

{{PMID|19956433|OA=1
}} Genetics of coronary artery disease: focus on genome-wide association studies.

{{PMID|20835900|OA=1
}} Genetics of diabetes complications.

{{PMID|22152955|OA=1
}} Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12526453
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23561647
|Title=Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}