{{Rsnum
|rsid=1255998
|Gene=ESR2
|Chromosome=14
|position=64227153
|Orientation=minus
|GMAF=0.3453
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ESR2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 84.1 | 14.3 | 1.6
| HCB | 17.8 | 55.6 | 26.7
| JPT | 27.3 | 52.3 | 20.5
| YRI | 17.7 | 37.1 | 45.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 17.8 | 55.6 | 26.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|17889406|OA=1
}}
Among women, [[rs8179176]], [[rs9340799]], [[rs1256065]], and [[rs1256030]] were associated with likelihood of developing cognitive impairment. In men, [[rs728524]], [[rs1255998]], and [[rs1256030]] were associated with cognitive impairment.

{{ neighbor
| rsid = 1256065
| distance = 5061
}}

{{PharmGKB
|RSID=rs1255998
|Name_s=ESR2:rs1255998
|Gene_s=SYNE2
|Feature=
|Evidence=PubMed ID:16949384; PubMed ID:16949390; PubMed ID:16949392
|Annotation=Associated with lower circulating estradiol concentration in Japanese premenopausal women.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145068
}}

{{PMID Auto
|PMID=18304720
|Title=Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.
}}

{{PMID Auto
|PMID=19337586
|Title=Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
|OA=1
}}

{{PMID Auto
|PMID=19438492
|Title=Estrogen receptor polymorphisms and the risk of endometrial cancer.
}}

{{PMID Auto
|PMID=19630952
|Title=Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.
|OA=1
}}

{{PMID Auto
|PMID=20304699
|Title=Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1255998
|overall_frequency_n=47
|overall_frequency_d=128
|overall_frequency=0.367188
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}