{{Rsnum
|rsid=1256031
|Gene=ESR2
|Chromosome=14
|position=64279461
|Orientation=plus
|GMAF=0.432
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ESR2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 20.4 | 47.8 | 31.9
| HCB | 19.0 | 48.9 | 32.1
| JPT | 21.2 | 49.6 | 29.2
| YRI | 10.2 | 39.5 | 50.3
| ASW | 14.0 | 42.1 | 43.9
| CHB | 19.0 | 48.9 | 32.1
| CHD | 17.4 | 51.4 | 31.2
| GIH | 21.8 | 49.5 | 28.7
| LWK | 11.9 | 44.0 | 44.0
| MEX | 32.8 | 46.6 | 20.7
| MKK | 14.7 | 43.6 | 41.7
| TSI | 20.6 | 38.2 | 41.2
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1256031
|Name_s=ESR2:rs1256031
|Gene_s=ESR2
|Feature=
|Evidence=PubMed ID:15068501; PubMed ID:16280269
|Annotation=Associated with femoral BMD in men and left ventricular mass and left ventricular wall thickness in women.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161148979
}}

{{PMID Auto
|PMID=20508921
|Title=Genotypes and Haplotypes of the Estrogen Receptor Genes, but Not the Retinoblastoma-interacting Zinc Finger Protein 1 Gene, Are Associated with Osteoporosis
}}
{{PMID Auto
|PMID=21080949
|Title=Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=16118344
|Title=Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women.
|OA=1
}}

{{PMID Auto
|PMID=17702854
|Title=Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women.
|OA=1
}}

{{PMID Auto
|PMID=17935138
|Title=Haplotypes of the estrogen receptor beta gene and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18445666
|Title=Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.
|OA=1
}}

{{PMID Auto
|PMID=18704709
|Title=Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19194457
|Title=Association between arterial stiffness and variations in oestrogen-related genes.
|OA=1
}}

{{PMID Auto
|PMID=19337586
|Title=Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
|OA=1
}}

{{PMID Auto
|PMID=19555469
|Title=A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19884274
|Title=The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand.
|OA=1
}}

{{PMID Auto
|PMID=20399928
|Title=Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma.
}}

{{PMID Auto
|PMID=20655613
|Title=Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1256031
|overall_frequency_n=76
|overall_frequency_d=126
|overall_frequency=0.603175
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23274843
|Title=Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}