{{Rsnum
|rsid=1256059
|Gene=ESR2
|Chromosome=14
|position=64243699
|Orientation=plus
|GMAF=0.3191
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ESR2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 34.5 | 47.8 | 17.7
| HCB | 46.7 | 46.0 | 7.3
| JPT | 41.6 | 45.1 | 13.3
| YRI | 89.8 | 10.2 | 0.0
| ASW | 80.7 | 15.8 | 3.5
| CHB | 46.7 | 46.0 | 7.3
| CHD | 45.0 | 47.7 | 7.3
| GIH | 28.7 | 52.5 | 18.8
| LWK | 90.9 | 9.1 | 0.0
| MEX | 29.3 | 46.6 | 24.1
| MKK | 83.3 | 16.7 | 0.0
| TSI | 44.1 | 36.3 | 19.6
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1256059
|Name_s=ESR2:rs1256059
|Gene_s=ESR2
|Feature=
|Evidence=PubMed ID:15068501; PubMed ID:16280269
|Annotation=Associated with femoral BMD in men and left ventricular mass and left ventricular wall thickness in women.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145063
}}

{{PMID Auto
|PMID=17702854
|Title=Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women.
|OA=1
}}

{{PMID Auto
|PMID=18445666
|Title=Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.
|OA=1
}}

{{PMID Auto
|PMID=19194457
|Title=Association between arterial stiffness and variations in oestrogen-related genes.
|OA=1
}}

{{PMID Auto
|PMID=19337586
|Title=Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
|OA=1
}}

{{PMID Auto
|PMID=19679043
|Title=African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19875614
|Title=A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
|OA=1
}}

{{PMID Auto
|PMID=19884274
|Title=The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand.
|OA=1
}}

{{PMID Auto
|PMID=20346360
|Title=Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1256059
|overall_frequency_n=95
|overall_frequency_d=128
|overall_frequency=0.742188
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=83
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24326520
|Title=Estrogen Receptor β Variants Modify Risk for Alzheimer's Disease in a Multiethnic Female Cohort
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}