{{Rsnum
|rsid=1256065
|Gene=ESR2
|Chromosome=14
|position=64232214
|Orientation=minus
|GMAF=0.32
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=ESR2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 34.5 | 45.1 | 20.4
| HCB | 46.0 | 46.7 | 7.3
| JPT | 40.7 | 46.9 | 12.4
| YRI | 90.5 | 9.5 | 0.0
| ASW | 80.7 | 15.8 | 3.5
| CHB | 46.0 | 46.7 | 7.3
| CHD | 45.9 | 45.9 | 8.3
| GIH | 28.7 | 51.5 | 19.8
| LWK | 90.9 | 9.1 | 0.0
| MEX | 29.3 | 46.6 | 24.1
| MKK | 83.3 | 16.7 | 0.0
| TSI | 44.1 | 36.3 | 19.6
| HapMapRevision=28
}}

{{PMID|17889406|OA=1
}}
Among women [[rs8179176]] [[rs9340799]] [[rs1256065]] and [[rs1256030]] were associated with likelihood of developing cognitive impairment. In men, one of the [[rs728524]] [[rs1255998]] [[rs1256030]] were associated with cognitive impairment.

{{ neighbor
| rsid = 1255998
| distance = 5061
}}

{{PharmGKB
|RSID=rs1256065
|Name_s=ESR2:rs1256065
|Gene_s=ESR2
|Feature=NA
|Evidence=PubMed ID:16949384; PubMed ID:16949390; PubMed ID:16949392
|Annotation=Associated with lumbar spine and HDL cholesterol concentration in Chinese premenopausal women.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145069
}}

{{PMID Auto
|PMID=19875614
|Title=A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1256065
|overall_frequency_n=95
|overall_frequency_d=128
|overall_frequency=0.742188
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=83
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}