{{Rsnum
|rsid=1258763
|Chromosome=15
|position=32758222
|Orientation=plus
|GMAF=0.4605
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.0 | 44.2 | 9.7
| HCB | 1.5 | 12.7 | 85.8
| JPT | 0.0 | 14.3 | 85.7
| YRI | 29.3 | 46.9 | 23.8
| ASW | 22.8 | 43.9 | 33.3
| CHB | 1.5 | 12.7 | 85.8
| CHD | 0.9 | 12.8 | 86.2
| GIH | 25.7 | 43.6 | 30.7
| LWK | 24.5 | 44.5 | 30.9
| MEX | 43.1 | 43.1 | 13.8
| MKK | 30.8 | 42.9 | 26.3
| TSI | 49.0 | 38.2 | 12.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20023658
|Trait=Nonsyndromic cleft lip with or without cleft palate
|Title=Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
|RiskAllele=A
|Pval=0.000001
|OR=1.52
|ORtxt=[1.23-1.86]
}}

[http://blogs.discovermagazine.com/gnxp/2011/06/heritability-and-genomics-of-facial-characteristics/ blog] The two most significant associations found were between nose width and SNP [[rs1258763]] near the GREM1 gene in the German cohort (P=6 × 10?4), and between bizygomatic distance and SNP [[rs987525]] at 8q24.21 near the CCDC26 gene (P=0.017) 

{{PMID|21694738|OA=1
}} Genetic determination of human facial morphology: links between cleft-lips and normal variation.

Associated with European Facial [[Appearance]] {{doi|10.1371/journal.pgen.1002932}}
*[[rs7590268]]
*[[rs16903544]]
*[[rs987525]]
*[[rs9574565]]
*[[rs227731]]
*[[rs642961]] 
*[[rs1258763]]

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1258763
|overall_frequency_n=67
|overall_frequency_d=124
|overall_frequency=0.540323
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22863734
  |Trait=Orofacial clefts
  |Title=Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
  |RiskAllele=
  |Pval=2E-6
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}