{{Rsnum
|rsid=12593813
|Gene=MAP2K5
|Chromosome=15
|position=67744514
|Orientation=plus
|GMAF=0.4545
|Gene_s=MAP2K5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.5 | 50.0 | 45.5
| HCB | 37.2 | 52.6 | 10.2
| JPT | 43.4 | 44.2 | 12.4
| YRI | 67.1 | 30.1 | 2.7
| ASW | 40.4 | 50.9 | 8.8
| CHB | 37.2 | 52.6 | 10.2
| CHD | 38.0 | 45.4 | 16.7
| GIH | 27.7 | 40.6 | 31.7
| LWK | 50.9 | 44.5 | 4.5
| MEX | 39.7 | 50.0 | 10.3
| MKK | 38.5 | 42.9 | 18.6
| TSI | 14.9 | 40.6 | 44.6
| HapMapRevision=28
}}[[rs12593813]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (A) minor allele. {{PMID|17637780}}
{{ neighbor
| rsid = 11635424
| distance = 726
}}

{{GWAS Summary
|SNP=rs12593813
|PubMedID=17637780
|Condition=Restless legs syndrome
|Gene=MAP2K5, LBXCOR1
|Risk Allele=G
|pValue=1.00E-015
|OR=1.5
|95CI=1.36-1.66
}}

{{PMID Auto
|PMID=19223043
|Title=Exploring the genetic link between RLS and [[ADHD]]
}}

{{PharmGKB
|RSID=rs12593813
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions (Initial Sample Size: 401 cases, 1,644 controls; Replication Sample Size: 1,158 cases, 1,178 controls; Risk Allele: rs12593813-G).
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356676
}}

{{PharmGKB
|RSID=rs12593813
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs12593813 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355629
}}

{{PMID Auto GWAS
|PMID=21779176
|Trait=None
|Title=Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
|RiskAllele=G
|Pval=1E-22
|OR=1.4100
|ORtxt=[1.32-1.52]
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12593813
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Restless Legs Syndrome: Preliminary Research]]

{{PMID Auto
|PMID=23543094
|Title=Testing for associations between loci and environmental gradients using latent factor mixed models.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}