{{Rsnum
|rsid=12597511
|Gene=PRSS8
|Chromosome=16
|position=31133898
|Orientation=plus
|GMAF=0.4692
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PRSS8
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 38.9 | 41.6 | 19.5
| HCB | 0.0 | 9.8 | 90.2
| JPT | 0.0 | 18.6 | 81.4
| YRI | 87.6 | 11.7 | 0.7
| ASW | 77.2 | 19.3 | 3.5
| CHB | 0.0 | 9.8 | 90.2
| CHD | 0.9 | 16.7 | 82.4
| GIH | 69.0 | 30.0 | 1.0
| LWK | 81.7 | 17.4 | 0.9
| MEX | 29.3 | 48.3 | 22.4
| MKK | 68.6 | 28.2 | 3.2
| TSI | 32.4 | 51.0 | 16.7
| HapMapRevision=28
}}
[[rs12597511]], a SNP in the serine protease prostasin [[PRSS8]] gene, has been linked to higher blood pressure (and thus risk of [[hypertension]]) in a study of healthy subjects.

Both African-Americans and European-Americans with [[rs12597511]](C;T) or [[rs12597511]](T;T) genotypes had (slightly) higher systolic and diastolic blood pressure than (C;C) individuals.{{PMID|18583984|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}