{{Rsnum
|rsid=12623467
|Gene=NRXN1
|Chromosome=2
|position=50997951
|Orientation=plus
|GMAF=0.2103
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NRXN1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 90.8 | 9.2 | 0.0
| HCB | 40.0 | 42.2 | 17.8
| JPT | 42.2 | 33.3 | 24.4
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 40.0 | 42.2 | 17.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}rs12623467 increases susceptibility to Substance dependence, Nicotine 2.09 times for carriers of the C allele {{PMID|17158188|OA=1
}}

{{PMID Auto
|PMID=18270208
|Title=Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.
|OA=1
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18783506
|Title=Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}