{{Rsnum
|rsid=1265181
|Chromosome=6
|position=31188008
|Orientation=minus
|GMAF=0.1102
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 54.7 | 39.1 | 6.2
| HCB | 86.4 | 13.6 | 0.0
| JPT | 97.7 | 2.3 | 0.0
| YRI | 95.2 | 4.8 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 86.4 | 13.6 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1265181]] is a SNP in the HLA region of chromosome 6.

A large study (>6,000 Chinese psoriasis patients and an equal number of controls) found a highly significant association between the minor [[rs1265181]](G) allele and risk for [[psoriasis]].{{PMID|19169255}} A proxy for this allele is [[rs1265159]](A).

See also:
[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 

{{PMID Auto GWAS
|PMID=19169255
|Trait=Psoriasis
|Title=Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
|RiskAllele=
|Pval=NS
|OR=22.62
|ORtxt=None
}}

{{PharmGKB
|RSID=rs1265181
|Name_s=
|Gene_s=HCG27
|Feature=
|Evidence=PubMed ID:19169255; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. (Initial Sample Size: 1,139 Chinese cases, 1,132 Chinese controls; Replication Sample Size: 5,721 Chinese cases, 7,340 Chinese controls); (Region: 6p21.33; Reported Gene(s): MHC; Risk Allele: rs1265181-?); (p-value= NS).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740046
}}

{{PMID Auto
|PMID=21208785
|Title=Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population
}}

{{PMID Auto
|PMID=19680446
|Title=Multiple Loci within the major histocompatibility complex confer risk of psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1265181
|overall_frequency_n=14
|overall_frequency_d=126
|overall_frequency=0.111111
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}