{{Rsnum
|rsid=12680546
|Chromosome=8
|position=135859496
|Orientation=plus
|GMAF=0.1671
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 44.6 | 47.3 | 8.0
| HCB | 77.4 | 21.2 | 1.5
| JPT | 82.1 | 17.9 | 0.0
| YRI | 93.2 | 6.8 | 0.0
| ASW | 78.9 | 21.1 | 0.0
| CHB | 77.4 | 21.2 | 1.5
| CHD | 75.2 | 24.8 | 0.0
| GIH | 76.2 | 21.8 | 2.0
| LWK | 89.1 | 10.9 | 0.0
| MEX | 62.1 | 32.8 | 5.2
| MKK | 64.1 | 30.1 | 5.8
| TSI | 47.1 | 47.1 | 5.9
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs12680546
|PubMedID=17362836
|Condition=Amyotrophic lateral sclerosis
|Gene=Intergenic
|Risk Allele=
|pValue=3.00E-006
|OR=1.67
|95CI=1.25-2.00
}}

{{PharmGKB
|RSID=rs12680546
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17362836; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data (Initial Sample Size: 276 cases, 276 controls; Replication Sample Size: NR). This variant is associated with Amyotrophic lateral sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Amyotrophic Lateral Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356536
}}

{{PMID Auto
|PMID=17052657
|Title=Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
}}

{{PMID Auto
|PMID=19740415
|Title=Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12680546
|overall_frequency_n=27
|overall_frequency_d=128
|overall_frequency=0.210938
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}