{{Rsnum
|rsid=12682807
|Gene=SLC1A1
|Chromosome=9
|position=4574022
|Orientation=plus
|GMAF=0.1189
|Gene_s=SLC1A1
|Assembly=GRCh37.p5
|GenomeBuild=37.3
|dbSNPBuild=137
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 77.9 | 21.2 | 0.9
| HCB | 58.4 | 37.2 | 4.4
| JPT | 72.6 | 25.7 | 1.8
| YRI | 100.0 | 0.0 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 58.4 | 37.2 | 4.4
| CHD | 60.6 | 33.9 | 5.5
| GIH | 94.1 | 5.9 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 81.0 | 17.2 | 1.7
| MKK | 99.4 | 0.6 | 0.0
| TSI | 83.3 | 15.7 | 1.0
| HapMapRevision=28
}}This SNP is located in the intronic region of the SLC1A1 transporter gene. While the mechanism is unknown, it is associated with [[Obsessive compulsive disorder]] (OCD). OCD is an anxiety disorder where symptoms include repetitive behaviors aimed at decreasing anxiety.

SLC1A1 is a candidate gene that has been the focus of many studies. Elevated glutamate levels have been found in the cerebrospinal fluid of many OCD patients, and since SLC1A1 affects glutamate transport – it is a likely candidate for study. SLC1A1 is expressed in the brain, and OCD is associated with neural changes. {{PMID|23606572}}

Rs12682807 is located in chr9:4564022 in the intronic region. It is an A to C transition. A study {{PMID|23606572}} looked at 21 SNPs in Europeans and originally found no correlation between rs12682807 and OCD (815 trios, 306 cases and 634 controls). However, upon later stratifying the family and case-control datasets by gender, they found that rs12682807 had a nominally significant uncorrected pvalue in males only (uncorrected P = 0.012, N = 358 trios and 133 cases). This association did not survive multiple testing correction.

Another study {{PMID|17894418}} looked at 13 SNPs in Europeans and the correlation of OCD and found n o single marker associations (Families of 66 probands meeting DSM-IV criteria for OCD were included in analyses). However, a three-marker haplotype spanning 4.2 KB and including the intronic SNP rs12682807, intronic SNP rs2072657, and synonymous exonic SNP rs301430, was associated with the OCD phenotype (P = 0.0043 or P = 0.0069 depending on rs2072657 SNP). The authors tested 10 different haplotype patterns.

These results are not significant based on the P-value of the experiments done and the number of hypotheses tested. More studies are needed to determine the association of OCD with rs12682807; however, current studies show (as evidence shown above) weak to no association of this SNP with OCD.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}