{{Rsnum
|rsid=1271572
|Gene=ESR2
|Chromosome=14
|position=64295199
|Orientation=minus
|GMAF=0.455
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ESR2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 34.9 | 46.0 | 19.0
| HCB | 47.7 | 45.5 | 6.8
| JPT | 39.0 | 46.3 | 14.6
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 47.7 | 45.5 | 6.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|18487282}} The [[rs1271572]](T) allele was significantly more common in patients who developed MI (P < 0.001), based on a study of 710 Spanish patients. This was statistically significant only in men [odds ratio 1.65, CI: 1.18-2.30; p = 0.003).

{{PMID|18704709|OA=1
}} Based on a study of 313 female patients, [[rs1271572]](T;T) homozygotes were at increased risk for epithelial [[ovarian cancer]]. The odds ratio was 1.79, CI:1.15-2.79, p global = 0.01.

{{PMID Auto
|PMID=19111408
|Title=Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene)
|OA=1
}}

{{PMID Auto
|PMID=19032032
|Title=Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women
|OA=1
}}

{{PharmGKB
|RSID=rs1271572
|Name_s=ESR2:(-)1839; ESR2:rs1271572
|Gene_s=ESR2
|Feature=
|Evidence=PubMed ID:15280642; PubMed ID:17579196; PubMed ID:17702854
|Annotation=Associated with increased risk of cardiovascular disease, no association with endometrial cancer.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145066
}}

{{PMID Auto
|PMID=19739075
|Title=Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy
}}

{{PMID Auto
|PMID=22511967
|Title=Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India
|OA=1
}}

{{PMID|16083630}} [Association between single-nucleotide polymorphisms in estrogen receptor beta gene and risk of prostate cancer].

{{PMID|18053221|OA=1
}} Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.

{{PMID|18304720}} Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.

{{PMID|18579753|OA=1
}} Vascular actions of estrogens: functional implications.

{{PMID|18627768}} Pharmacogenetics of hormone replacement therapy for climacteric symptoms.

{{PMID|19337586|OA=1
}} Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?

{{PMID|19654868|OA=1
}} Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.

{{PMID Auto
|PMID=22970307
|Title=Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1271572
|overall_frequency_n=45
|overall_frequency_d=126
|overall_frequency=0.357143
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=47
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23711151
|Title=Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}